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Wednesday, October 21, 2009

Sperm Donor Passed on Sudden Death Heart Defect

MedicalRF.com / CorbisAn illustration of human sperm. (CHICAGO) -- A sperm donor passed on a potentially deadly genetic heart condition to nine of his 24 children, including one who died at age 2 from heart failure, according to a medical journal report.Two children, both now teenagers, have developed symptoms and are at risk for sudden cardiac death, the report says. It's the second documented instance of a genetic condition being inherited through sperm donation.The latest case highlights the importance of thoroughly screening sperm donors, according to the report and an editorial published with it in Wednesday's Journal of the American Medical Association.The San Francisco sperm bank involved now gives all donors electrocardiogram tests to weed out men with genetic heart problems; the study authors recommend that other sperm banks follow suit.Voluntary sperm bank guidelines say donors should be required to provide a complete medical history to rule out those with infectious diseases or a family history of inherited diseases. Many also do testing but for genetic diseases that are less common than the heart problem, according to co-author Dr. Barry Maron of the Minneapolis Heart Institute, a leading authority on the condition called hypertrophic cardiomyopathy.Hypertrophic cardiomyopathy thickens the heart and makes it harder to pump blood. It affects about one in 500 people; many more likely have the genetic defect without symptoms, said study co-author Heidi Rehm of Harvard Medical School.
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http://www.time.com/time/health/article/0,8599,1931281,00.html
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